The Moorebank site is located in the Liverpool Local Government Area. It is 27 kilometres west of the Sydney CBD, 17 kilometres south of the Parramatta CBD, five kilometres east of the M5/M7 Interchange, two kilometres from the main north-south rail line and Southern Sydney Freight Line and 600 metres from the M5 motorway.

The SIMTA site (now known as MPE) covers approximately 83 hectares and was formerly the Defence National Storage and Distribution Centre (DNSDC). The MIC site (now known as MPW) is adjacent to the SIMTA site, west of Moorebank Avenue. This site covers 220 hectares and was previously the School of Military Engineering.